Protective effect of IAXO-102 on renal ischemia-reperfusion injury in rats Yahiya Ibrahim Yahiya, Najah Rayish Hadi, Ahmed Abu Raghif, Noor Ghaffar Said Al Habooby Abstract Ischemia/reperfusion injury (IRI) is a common cause of kidney damage, characterized by oxidative stress and inflammation. In this study, we investigated the potential protective effects of IAXO-102, a
Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages Charys Palmer, Fabio A Facchini, Richard PO Jones, Frank Neumann, Francesco Peri, and Grisha Pirianov Abstract TLRs, including TLR4, play a crucial role in inflammatory-based diseases, and TLR4 has been identified as a therapeutic target for pharmacological intervention. In previous studies, we investigated the potential of
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice Deebika Balu, Ana C. Valencia-Olvera, Austin Nguyen, Mehul Patnam, Jason York, Francesco Peri, Frank Neumann, Mary Jo LaDu & Leon M. Tai Abstract Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is greater in
Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance J Neural Eng. 15:025002 (2018) Hermann JK1, Ravikumar M, Shoffstall AJ, Ereifej ES, Kovach KM, Chang J, Soffer A, Wong C, Srivastava V, Smith P, Protasiewicz G, Jiang J, Selkirk SM, Miller RH, Sidik
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria Sci Rep. 7:8623 (2017) Barboza R1, Lima FA2, Reis AS2, Murillo OJ2, Peixoto EPM2, Bandeira CL2, Fotoran WL2, Sardinha LR3, Wunderlich G2, Bevilacqua E4, Lima MRD5, Alvarez JM5, Costa FTM6, Gonçalves LA2, Epiphanio S7, Marinho CRF8. Abstract Malaria-associated pregnancy has a
Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice Mol Neurobiol. 54:6624-6633 (2017) Kawakita F1, Fujimoto M1, Liu L1, Nakano F1, Nakatsuka Y1, Suzuki H2. Abstract Toll-like receptor 4 (TLR4) signaling may play a crucial role in the occurrence of cerebral vasospasm after subarachnoid hemorrhage
Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model (2016) Pharmacol Res. 103:180 (2016) De Paola M1, Sestito SE2, Mariani A3, Memo C3, Fanelli R3, Freschi M4, Bendotti C4, Calabrese V2, Peri F5. 1 Department of Environmental Health Sciences, IRCCS-Istituto di Ricerche Farmacologiche “Mario
A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development (2015) Atherosclerosis. 242:563 (2015) Huggins C1, Pearce S1, Peri F2, Neumann F3, Cockerill G1, Pirianov G4. 1 Institute of Cardiovascular Sciences and Cell Biology, St Georges University of London, UK 2 Department of
Toll like Receptor 4 antagonist prevents acetaminophen induced acute liver failure in mice: A novel therapeutic strategy Key role for TLR4 in ALF (April 2012) EASL, Barcelona, Spain N. Shah, D. Dhar, M. Jover, N.A. Davies, R.P. Mookerjee, R. Jalan UCL, Institute of Hepatology, London, UK Background and aim Without