A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice Deebika Balu, Ana C. Valencia-Olvera, Austin Nguyen, Mehul Patnam, Jason York, Francesco Peri, Frank Neumann, Mary Jo LaDu & Leon M. Tai Abstract Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is greater in
Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance J Neural Eng. 15:025002 (2018) Hermann JK1, Ravikumar M, Shoffstall AJ, Ereifej ES, Kovach KM, Chang J, Soffer A, Wong C, Srivastava V, Smith P, Protasiewicz G, Jiang J, Selkirk SM, Miller RH, Sidik
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria Sci Rep. 7:8623 (2017) Barboza R1, Lima FA2, Reis AS2, Murillo OJ2, Peixoto EPM2, Bandeira CL2, Fotoran WL2, Sardinha LR3, Wunderlich G2, Bevilacqua E4, Lima MRD5, Alvarez JM5, Costa FTM6, Gonçalves LA2, Epiphanio S7, Marinho CRF8. Abstract Malaria-associated pregnancy has a