Protective effect of IAXO-102 on renal ischemia-reperfusion injury in rats Yahiya Ibrahim Yahiya, Najah Rayish Hadi, Ahmed Abu Raghif, Noor Ghaffar Said Al Habooby Abstract Ischemia/reperfusion injury (IRI) is a common cause of kidney damage, characterized by oxidative stress and inflammation. In this study, we investigated the potential protective effects of IAXO-102, a
Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice Mol Neurobiol. 54:6624-6633 (2017) Kawakita F1, Fujimoto M1, Liu L1, Nakano F1, Nakatsuka Y1, Suzuki H2. Abstract Toll-like receptor 4 (TLR4) signaling may play a crucial role in the occurrence of cerebral vasospasm after subarachnoid hemorrhage
A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development (2015) Atherosclerosis. 242:563 (2015) Huggins C1, Pearce S1, Peri F2, Neumann F3, Cockerill G1, Pirianov G4. 1 Institute of Cardiovascular Sciences and Cell Biology, St Georges University of London, UK 2 Department of