A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice Deebika Balu, Ana C. Valencia-Olvera, Austin Nguyen, Mehul Patnam, Jason York, Francesco Peri, Frank Neumann, Mary Jo LaDu & Leon M. Tai Abstract Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is greater in
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria Sci Rep. 7:8623 (2017) Barboza R1, Lima FA2, Reis AS2, Murillo OJ2, Peixoto EPM2, Bandeira CL2, Fotoran WL2, Sardinha LR3, Wunderlich G2, Bevilacqua E4, Lima MRD5, Alvarez JM5, Costa FTM6, Gonçalves LA2, Epiphanio S7, Marinho CRF8. Abstract Malaria-associated pregnancy has a
Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model (2016) Pharmacol Res. 103:180 (2016) De Paola M1, Sestito SE2, Mariani A3, Memo C3, Fanelli R3, Freschi M4, Bendotti C4, Calabrese V2, Peri F5. 1 Department of Environmental Health Sciences, IRCCS-Istituto di Ricerche Farmacologiche “Mario
A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development (2015) Atherosclerosis. 242:563 (2015) Huggins C1, Pearce S1, Peri F2, Neumann F3, Cockerill G1, Pirianov G4. 1 Institute of Cardiovascular Sciences and Cell Biology, St Georges University of London, UK 2 Department of